John W. Tyrone, M.D.

2002

Tyrone, J. W., Losken, A., & Hester, T. R. (2002). Nipple areola reconstruction. Breast disease, 16, 117–122.
Excerpt: “Creation of the nipple areolar complex often represents the final hurdle in a long and arduous reconstructive process for women with breast cancer. …”

2001

Xia, Y. P., Zhao, Y., Tyrone, J. W., Chen, A., & Mustoe, T. A. (2001). Differential activation of migration by hypoxia in keratinocytes isolated from donors of increasing age: implication for chronic wounds in the elderly. The Journal of investigative dermatology, 116(1), 50–56.
Excerpt: “Chronic wound healing conditions are often observed in elderly patients with poor tissue oxygenation. Impaired re-epithelialization is a hallmark of these wounds, …”

2000

Tyrone, J.W., Mogford, J.E., Chandler, L.A., Ma, C., Xia, Y., Pierce, G.F., & Thomas A. Mustoe, M.F. (2000). Collagen-embedded platelet-derived growth factor DNA plasmid promotes wound healing in a dermal ulcer model. The Journal of surgical research, 93 2, 230-6 .
Excerpt: “Gene therapy has shown limited efficacy for treating congenital diseases, partly due to temporary gene expression and host immune responses. …”

Tyrone, J.W., Marcus, J.R., Bonomo, S.R., Mogford, J.E., Xia, Y., & Thomas A. Mustoe, M.F. (2000). Transforming growth factor beta3 promotes fascial wound healing in a new animal model. Archives of surgery, 135 10, 1154-9 .Hypothesis: “Transforming growth factor beta(3) (TGF-beta(3)) promotes fascial wound healing in a new animal model, as measured by wound breaking strength, collagen deposition, and cellular proliferation.”

Marcus, J.R., Tyrone, J.W., Bonomo, S.R., Xia, Y., & Thomas A. Mustoe, M.F. (2000). Cellular Mechanisms for Diminished Scarring with Aging. Plastic and Reconstructive Surgery, 105, 1591–1599.
Excerpt: “The study of an age‐dependent spectrum of scar formation is driven by the desire to understand and recapitulate scarless healing. …”

1999

Abstract Presentation: “Topical Platelet-Derived Growth Factor Gene Therapy Enhances Wound Healing”, University of California, Davis Surgical Forum, Sacramento, California, June 1999. UCD “Best Paper – UCD Residents’ Research Day Award”.

Abstract Presentation: “A Novel Gene Therapy Approach To Wound Healing: Topical Plasmid Platelet-Derived Growth Factor DNA Without A Viral Vector”, American College of Surgeon Surgical Forum Manual. Oct 1999

Abstract Presentation: “Neutralization of Transforming Growth Factor Beta Isoforms 1,2, and 3 Delays Wound Closure in Full-thickness Dermal Ulcers”, American College of Surgeon Surgical Forum. Oct 1999

Chao JD, Tyrone JW, Xia Y, Mustoe TA (Oct 1999). Neutralization of Transforming Growth Factor Beta Isoforms 1,2, and 3 Delays Wound Closure in Full-thickness Dermal Ulcers, American College of Surgeon Surgical Forum Manual.

Tyrone JW, Mustoe TA (1999). Chapter 1: The Principles of Wound Healing in Plastic Surgery Secrets, ed. J. Weinzweig, 1st Edition, Hanley & Belfus, Philadelphia.

Marcus, J.R., Tyrone, J.W., Few, J.W., Fine, N.A., & Thomas A. Mustoe, M.F. (1999). Optimization of conscious sedation in plastic surgery. Plastic and reconstructive surgery, 104 5, 1338-45 .Excerpt: “The administration of conscious sedation by the plastic surgeon must be safe, efficient, and consistent. In the proper setting, with trained staff and appropriate backup, conscious sedation can allow optimal patient satisfaction with expedient recovery in addition to cost containment. …”

1998

Abstract Presentation: “Effects of Hyperbaric Oxygen, TGF-b3 and Combination Treatment on a New Chronic Wound Model”, Wound Healing Society, Salt Lake City, Utah, June 1998

Abstract Presentation: “TGF-β3 Improves Fascial Healing in a New Animal Model” University of California, Davis Surgical Forum, Oakland, California, June 1998

Abstract Presentation: “TGF-β3 Improves Fascial Healing in a New Animal Model”, European Tissue Repair Society, Copenhagen, Denmark, September 1998

Poster: “Computer Aided Histological Analysis: New Techniques” European Tissue Repair Society, Copenhagen, Denmark, September 1998

Abstract Presentation: Marcus, J.R., Tyrone, J.W., Few, J.W., Fine, N.A., & Thomas A. Mustoe, M.F. (1999). Optimization of conscious sedation in plastic surgery. Plastic and reconstructive surgery, 104 5, 1338-45 .